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Based on the results of these studies, Aclasta was licensed for the treatment of Paget's disease in all 25 European Union member states, as well as Norway and Iceland, in April 2005.
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Ocular infection: Conjunctivitis, uveitis, episcleritis, iritis, scleritis, and orbital inflammation have been reported (infrequently) with use; further ophthalmic evaluation (and possibly therapy discontinuation) may be necessary in patients with complicated infection.
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According to a meta-analysis of eight studies, an overall 10% reduction in mortality is achievable with osteoporosis pharmacotherapy; this benefit is clearest for older, frailer individuals at high risk of fracture ().
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Data from the study net predefined safety endpoints in the treatment of patients with long-term non-union tibial fractures, allowing the company to expand into the phase II stage of the trial and enroll patients with appendicular, or fresh, non-union fractures.
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In individuals determined to have risk factors, BMD should be measured with dual-energy x-ray absorptiometry(see next slide)Suspected vertebral fractures unrelated to trauma are best defined (on lateral x-rays or by vertebral fracture assessment) as vertebral height loss of 25% or more with disruption of the end plate.
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