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Ranolazine was reported to cause greater inhibition of sodium channels in atrial than in ventricular tissue (Burashnikov et al.
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In another aspect, the invention is directed to a method for reducing the prolongation of the QT interval in a patient caused by dronedarone or salt or salts thereof, wherein the method comprises administering to the patient a synergistically therapeutic amount of ranolazine or salt or salts thereof.
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Anti-anginal efficacy and safety were similar in both groups, but ranolazine reduced hemoglobin A1c levels in diabetics compared to placebo (0.
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Although the data are variable, diabetes and insulin resistance are also associated with an increase in the amount of cardiac LPL present on the luminal surface of endothelial cells, an effect accompanied by a decrease in cardiac myocyte LPL, thereby suggesting increased secretion of LPL (see Ref.
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Data for the first quarter (Q1, 1 January to 30 March) of 2007 are currently available at time of writing (MedWatch, 2007).
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APD 50 was not altered by ranolazine in either atria or ventricles ( FIG.
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The ideal forms of the apparatus for administration of the novel combinations for atrial fibrillation and other methods of the invention consist therefore of (1) either a syringe comprising 2 compartments containing the 2 active substances ready for use or (2) a kit containing two syringes ready for use.
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