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Additional limitations included the use of different inclusion criteria across studies assessing the same treatment, poorly-defined patient groups or use of patient groups with limited generalizability to the typical clinical setting in which OAB patients are seen, lack of consistency in outcome measures and limited outcome measure and adverse event reporting.
The population included both naïve patients who had not received prior antimuscarinic pharmacotherapy for overactive bladder (48%) and those who had received prior antimuscarinic pharmacotherapy for OAB (52%).
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Sometimes overactive bladder can be managed with lifestyle changes, such as: not drinking too much fluid; keeping a bladder diary to find factors causing symptoms; avoiding caffeine and alcohol; eating a high-fiber diet; wearing absorbent pads or underwear; and performing pelvic exercises (e.
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Published evidence was identified by applying systematic search strategies (see Appendix E in the full version of the original guideline document) to the following databases: Medline (1950 onwards), EMBASE (1980 onwards), Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 onwards), and three Cochrane databases (Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and the Database of Abstracts of Reviews of Effects).
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The method according to claim 15, wherein the solifenacin or pharmaceutically acceptable salt thereof is administered in a dose selected from the group consisting of 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 10 mg, 12 mg, 14 mg, 15 mg, 16 mg and 20 mg.
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The majority of anticholinergic drugs are antimuscarinics.
The chart review included assessment of body mass index (BMI) (primary outcome), and specific cardiovascular (BP, HR and QTc interval) and metabolic parameters (lipid panel, fasting blood glucose of HbA1c) as secondary outcomes.
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Van Kerrebroeck P, Kreder K, Jonas U et al: Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder.
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